R2D2 Leads the Silencing Trigger to mRNA's Death Star
نویسندگان
چکیده
During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi.
منابع مشابه
Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1
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ورودعنوان ژورنال:
- Cell
دوره 115 شماره
صفحات -
تاریخ انتشار 2003